Headshot of Bonni Goldstein

Bonni Goldstein, MD
Medical Director / Owner
Canna-Centers Wellness
ADVISORY BOARD MEMBER
MEDICINE

Applying Machine Learning Tools to the ASD Cannabis‑Responsive™ Biomarker Database: Paving the way

Cannabis‑responsive™ (C-Res™) biomarkers are metabolites found in saliva of patients that change in response to medical cannabis (MC) treatment. This objective technology characterizes treatment as successful when C-Res™ values shift to the physiological range determined by typically-developing control groups, and is especially relevant for medical conditions where evaluation of treatment currently relies on subjective evaluation. In a proof-of-concept study, we have demonstrated that the levels of C-Res™ biomarkers found in children with autism spectrum disorder (ASD) shift towards the physiological levels detected in typically developing (TD) children in response to successful physician-directed MC treatment (Siani-Rose et al, 2021 and 2022).

Learning Objectives:

  • Identify biomarkers distinguishing ASD and TD groups
  • Show the phytochemical entourage effect
  • Demonstrate that THC and CBD are associated with two distinct groups of C-Res™ biomarkers, while CBG is associated with some biomarkers from both groups
BIO

Bonni Goldstein, MD is the Medical Director of Canna-Centers Wellness & Education, a leading cannabis medicine specialty practice, and the CEO of GoldsteinWellness.com, an educational platform dedicated to helping licensed healthcare professionals incorporate medical cannabis into their practices.

Dr. Goldstein completed her internship and residency at Children’s Hospital Los Angeles, where she also served as chief resident. After years of practicing Pediatric Emergency Medicine, she became interested in the science of medical cannabis following the profound improvements she witnessed in a seriously ill friend using cannabis.

Dr. Goldstein has evaluated thousands of patients for medical cannabis treatment over the past 17 years. She has a special focus on treating children with intractable epilepsy, autism, and cancer. She has co-authored numerous papers on the use of pharmacometabolomics to study the impact of medical cannabis on the behavioral symptoms associated with autism. Dr. Goldstein is the author of the book Cannabis is Medicine: How Medical Cannabis and CBD are Healing Everything from Anxiety to Chronic Pain, and serves on the board of the International Alliance for Cannabinoid Medicine and Autism Safe Haven. Additionally, she is a medical advisor to Cannformatics and Weedmaps. She has been the medical director for the CannMed Conference Medical Practicum since 2022.

ATTENDANCE IS LIMITED. THE OPPORTUNITIES ARE NOT.

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