Review preclinical and clinical findings regarding the effect of combining cannabinoids for therapeutic effects.

The cannabis plant is an incredible source of therapeutic compounds, and in recent years selective breeding efforts have helped consumers access a variety of previously rare naturally-occurring cannabinoids like CBG and THCV. The acidic cannabinoids are receiving more attention as powerful tools, and old assumptions about the effects of combining THC and CBD are being questioned. The cannabinoids are versatile in treating a wide range of symptoms and disease processes, and it is becoming increasingly difficult to decide which type of cannabis may be best suited for a given patient.

Learning Objectives:

• Describe the clinically-relevant pharmacokinetic and pharmacodynamic interactions among major cannabinoids

• Understand the complex interactions between THC and CBD that go beyond standard beliefs of synergistic therapeutic effects and reduction of adverse effects
  
  
• Develop a strategic framework for using THC, CBD, CBG, THCV, and acidic cannabinoids for product design and patient treatment