Smoking is the most common and historically enduring method of cannabis consumption, yet despite its popularity, the chemistry of what occurs when cannabinoids are combusted isn’t commonly discussed. While differences between the effects of smoked and ingested cannabis are often attributed to first-pass metabolism and pharmacokinetic variation, the transformation of phytocannabinoids into thermally derived compounds - known as 'pyrocannabinoids' - likely plays a major role. To explore these transformations, we examined the combustion products of three cannabinoid isolates - CBD, THCV, and THCA. Using patented selective capture technology from Real Isolates LLC, combusted isolate smoke was collected and analyzed alongside unsmoked isolates via UHPLC-PDA and GC-MS by Smithers. The results revealed noticeable differences before and after combustion: each pure isolate initially displayed a single dominant peak, while post-combustion samples exhibited multiple new peaks indicative of degradation and the formation of additional cannabinoids such as CBE, CBT, and CBND. These findings confirm that combustion and thermal degradation of cannabinoids results in transformations generating multiple reaction products with potential biological relevance. The results underscore the importance of further research into the chemistry and safety of smoke-derived compounds to better understand the pharmacological implications of cannabis inhalation and its distinction from other delivery methods.